In 1925, five valiant women possessing a simple and sincere faith in God embarked on a great task. The city of Bayonne was sorely in need of a Catholic high school and the Sisters of St. Joseph created a secondary institution which would provide for the intellectual and spiritual needs of the city's youth. Through prayer and perseverance, the sisters secured buildings; and soon a new educational trend came into being, a trend which was destined to grow to great proportions.

Holy Family opened its doors for the first time in September 1925 in the Clark residence at 115 West Eighth Street. The first students, six boys and forty-three girls, continued the commercial course they had begun at St. Mary's and graduated in June, 1926. Enrollment rapidly increased and soon the property at 109 and 119 West Eighth Street was acquired to meet the need. A four year program was initiated and the school, after being accredited, graduated its first four-year class in June 1929.

As the years passed, the faculty incorporated studies, activities, athletics and clubs to suit the individual tastes of the students. In 1949, the last coeducational class graduated from Holy Family. In 1954, the present building at 239 Avenue A was dedicated and shortly after the Marist Brothers began a school for young men in the Eighth Street buildings. Since 1954 building projects have expanded the Avenue A building so that now, in addition to the original fifteen classrooms, auditorium/gymnasium and cafeteria, there are state of the art science labs, computer labs, an art studio, a library media center, health, guidance and other offices.

Holy Family Academy has emerged as an outstanding institution of learning, meeting preferences for a cultural, intellectual, and spiritual education for young women. Fully accredited by the Middle States Association of Colleges and Schools, Holy Family's curricular and co-curricular programs help students prepare for schools of higher education and successful careers.